In the 1974 movie Benji, a Maltese had a small role as Tiffany, a dog that Benji befriends.
The Maltese Dog, a short movie from 2015, starred Skipper The Maltese. The story revolves around two FBI agents, Fong and Wong, solving the dognapping of the famous movie star Skipper the Maltese (the dog's name did not change for the movie)
A 2011 animated movie called Cinnamon (straight to DVD release), was about a Maltese dog's role in helping two single parents break up but then come together. Brenda Song, an American actress, model, and spokesperson was the voice of Cinnamon.
A TV show called Lucky Dog, which focuses on re-homing hard-to-place dogs featured a Maltese mix.